Gleadle J M, Ratcliffe P J
Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK.
Mol Med Today. 1998 Mar;4(3):122-9. doi: 10.1016/s1357-4310(97)01198-2.
The optimal delivery of oxygen to tissues is essential both to ensure adequate energy provision and to avoid the toxic effects of higher oxygen concentrations. For this to occur, organisms must be able to sense oxygen and respond to changes in oxygen tension by altering gene expression. The analysis of the regulation of erythropoiesis has provided important insights into the mechanisms of oxygen-regulated gene expression. These mechanisms have a role in the regulation of many genes, in many cell types and appear to be of relevance to many common pathologies in which disturbances of oxygen supply are central.
向组织最佳地输送氧气对于确保充足的能量供应以及避免较高氧浓度的毒性作用都至关重要。要实现这一点，生物体必须能够感知氧气，并通过改变基因表达来应对氧张力的变化。对红细胞生成调节的分析为氧调节基因表达的机制提供了重要见解。这些机制在许多细胞类型中对许多基因的调节起作用，并且似乎与许多以氧供应紊乱为核心的常见病理状况相关。
