Itoh T, Ohtsubo S, Natsuaki M
Department of Thoracic and Cardiovascular Surgery, Saga Medical School, Japan.
Nihon Geka Gakkai Zasshi. 1998 Feb;99(2):99-104.
Between 1984 and 1997, 127 patients in our institution underwent single aortic valve replacement (AVR) with the St. Jude Medical valve (group S) and 11 patients with a porcine pericardial valve (group T). In the same period, 45 patients underwent aortic root reconstruction, among which 39 patients underwent the Bentall procedure using Carrel patch coronary reanastomosis (group B). The other 6 patients were treated with valve-sparing aortic root reconstruction (group V), among which the reimplantation method was used in 4 patients and the remodeling method in 2. The mean and total follow-up periods of the AVR and aortic root reconstruction groups were 6.9 +/- 1.9 year/735 patient-years and 4.9 +/- 3.9/years/196 patient-years respectively. The actuarial overall survival rates in group S and T at 10 years were; 73.8 +/- 7.0% and 85.7 +/- 13.0%, respectively The probabilities of freedom from reoperation at 12 years in group S and T were 97.7 +/- 2.3% and 62.5 +/- 21.3%, respectively. Only one patient in group S required reoperation because of valve thrombosis, while 2 patients in group T underwent reoperation for prosthetic valve endocarditis. The actuarial overall survival rate after aortic root reconstruction at 10 years was 62.6 +/- 9.6%, while that of patients with acute aortic dissection and those who did not were 44.4 +/- 15.7% and 71.7 +/- 11.5%, respectively. The event-free rate at 12 years after aortic root reconstruction (group V+B) was 79.1% +/- 20/9%. The reason for reoperation in the 2 patients who underwent the Bentall procedure were prosthetic valve endocarditis in one and psuedoaneurysm at the right coronary anastomosis in the other. The reason for reoperation in one patient who formed a pseudoaneurysm was likely due to an oversized conduit hole for the Carrel patch coronary anastomosis. One patient in whom the native valve was preserved using the David reimplantation procedure required reoperation because of valve degeneration 17 months after the initial surgery, possibly due to valve rubbing on the vascular conduit because of a modified geometry of the Valsalva sinuses. In conclusion, because of the low rate of long-term mortality and reoperation, the St. Jude Medical valve is an excellent prosthesis for AVR. AVR with a porcine pericardial valve yields favorable results in terms of the low long-term mortality although the incidence of reoperation remains high. Aortic root reconstruction with the Bentall procedure using the Carrel patch method yields acceptable results in terms of long-term mortality and low rate of reoperation, although acute aortic dissection is an incremental preoperative risk factor. The early results of aortic valve-sparing root reconstructive surgery are encouraging, with excellent clinical outcomes and patient quality of life. Nevertheless, the indications for the procedure must be carefully considered.
1984年至1997年间,我院127例患者接受了使用圣犹达医疗瓣膜的单纯主动脉瓣置换术(AVR)(S组),11例患者接受了猪心包瓣膜置换术(T组)。同期,45例患者接受了主动脉根部重建术,其中39例患者采用带Carrel补片冠状动脉再吻合术的Bentall手术(B组)。另外6例患者接受了保留瓣膜的主动脉根部重建术(V组),其中4例采用再植入法,2例采用重塑法。AVR组和主动脉根部重建组的平均随访期和总随访期分别为6.9±1.9年/735患者年和4.9±3.9年/196患者年。S组和T组10年的精算总生存率分别为73.8±7.0%和85.7±13.0%。S组和T组12年免于再次手术的概率分别为97.7±2.3%和62.5±21.3%。S组仅1例患者因瓣膜血栓形成需要再次手术,而T组2例患者因人工瓣膜心内膜炎接受了再次手术。主动脉根部重建术后10年的精算总生存率为62.6±9.6%,而急性主动脉夹层患者和非急性主动脉夹层患者的精算总生存率分别为44.4±15.7%和71.7±11.5%。主动脉根部重建术后(V组+B组)12年的无事件发生率为79.1%±20/9%。接受Bentall手术的2例患者再次手术的原因,1例是人工瓣膜心内膜炎,另1例是右冠状动脉吻合处假性动脉瘤。1例形成假性动脉瘤的患者再次手术的原因可能是Carrel补片冠状动脉吻合处的管道孔过大。1例采用David再植入术保留自体瓣膜的患者在初次手术后17个月因瓣膜退变需要再次手术,可能是由于主动脉窦几何形状改变导致瓣膜与血管管道摩擦。总之,由于长期死亡率和再次手术率较低,圣犹达医疗瓣膜是AVR的优良假体。猪心包瓣膜置换术虽然再次手术率仍然较高,但长期死亡率较低,取得了良好的效果。采用带Carrel补片法的Bentall手术进行主动脉根部重建,尽管急性主动脉夹层是术前增加的危险因素,但在长期死亡率和再次手术率方面取得了可接受的结果。保留主动脉瓣根部重建手术的早期结果令人鼓舞,临床效果和患者生活质量都非常好。然而,必须仔细考虑该手术的适应症。