Stefani F H
Klin Monbl Augenheilkd. 1976 May;168(05):716-8.
In 14 out of 25 patients with retinoblastoma there was a family history of malignancies. Most of the malignant tumours had been carcinomas. In 2 families relatives died because of leukaemia; in these cases the tumour was a so-called diffuse retinoblastoma occurring in elder children. A third family with a retinoblastoma in one child and leukaemia in another is mentioned. This unusual coincidence of two tumourous conditions of which one might be of viral origin led to detailed electron microscopic examination of the retinoblastoma in one case; but there were no signs of reduplicating viruses.
25例视网膜母细胞瘤患者中，有14例有恶性肿瘤家族史。大多数恶性肿瘤为癌。在2个家族中，亲属死于白血病；在这些病例中，肿瘤是发生在较大儿童中的所谓弥漫性视网膜母细胞瘤。还提到了第三个家族，其中一个孩子患视网膜母细胞瘤，另一个孩子患白血病。这两种肿瘤情况的异常巧合，其中一种可能源于病毒，导致对其中1例视网膜母细胞瘤进行了详细的电子显微镜检查；但没有发现病毒复制的迹象。
