Reshetniak T M, Derksen R V, Alekberova Z S, Horbach D, De Groot F, Nasonov E L, Kalashnikova L A, Match E S, Nasonova V A
Klin Med (Mosk). 1998;76(3):36-40.
Antibodies to beta 2-glycoprotein in the serum of patients with antiphospholipid syndrome (APS) were found by many investigators, but their results appeared contraversional. We studied clinical significance of antibodies to beta 2-glycoprotein I (anti-beta 2-GPI) in patients with SLE. 69 patients with verified SLE were examined for lupus anticoagulant (LA), antibodies to cardiolipin (aCL) and anti-beta 2-GPI. 44(65%), 46(67%), 49(71%), 19(28%), 16(23%) patients were positive for LA, IgG-aCL, IgM-aCL, IgG-anti-beta 2-GPI and IgM-anti-beta 2-GPI, respectively. Hyperproduction of IgG-anti-beta 2-GPI correlated with APS development as a whole, its separate clinical symptoms (venous and arterial thromboembolism, obstetric pathology and thrombocytopenia) and some comcomitant clinical signs (trophic crural ulcer, hemolytic anemia, valvular heart disorders). Moreover, an increase in concentration of IgM-anti-beta 2-GPI was associated with habitual abortion. Both isotypes of anti-beta 2-GPI occurred more frequently in the sera positive by LA and aCL. It is interesting that we discovered IgG-anti-beta 2-GPI more often in early than late postthrombolytic period. Thus, anti-2b2-GPI is a new serological marker of APS. Its detection is clinically important for upgrading diagnosis of APS.
许多研究人员在抗磷脂综合征（APS）患者血清中发现了抗β2-糖蛋白抗体，但其结果似乎存在争议。我们研究了系统性红斑狼疮（SLE）患者中抗β2-糖蛋白I（抗β2-GPI）抗体的临床意义。对69例确诊为SLE的患者进行了狼疮抗凝物（LA）、抗心磷脂抗体（aCL）和抗β2-GPI检测。LA、IgG-aCL、IgM-aCL、IgG-抗β2-GPI和IgM-抗β2-GPI阳性的患者分别为44例（65%）、46例（67%）、49例（71%）、19例（28%）、16例（23%）。IgG-抗β2-GPI的过度产生与整个APS的发生发展、其单独的临床症状（静脉和动脉血栓栓塞、产科病理和血小板减少症）以及一些伴随的临床体征（小腿营养性溃疡、溶血性贫血、心脏瓣膜疾病）相关。此外，IgM-抗β2-GPI浓度的升高与习惯性流产有关。两种抗β2-GPI亚型在LA和aCL阳性血清中出现的频率更高。有趣的是，我们发现溶栓后期血清中IgG-抗β2-GPI的出现频率低于早期。因此，抗β2-GPI是APS的一种新的血清学标志物。其检测对提高APS的诊断水平具有重要临床意义。
