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对类狼疮综合征的一项研究。心血管系统、腹部器官、淋巴系统及用药史的调查(作者译)

[A contribution to the pseudo-LE-syndrome. Investigations of the cardiovascular system, abdominal organs, lymphatic system and drug histories (author's transl)].

作者信息

Senekamp J, Genth E, Flenker I, Hermanutz H, Wagner J, Beltz L, Rohner H G

出版信息

Klin Wochenschr. 1976 Aug 15;54(16):755-63. doi: 10.1007/BF01614292.

Abstract

13 of 30 patients suffering from pseudo-LE-syndrome showed a usually reversible enlargement of the heart during the acute stage of the disease. In two patients carditis occurring in pseudo-LE-syndrome lead to congestive heart failure and an additional patient died in the acute stage of carditis. As opposed to Systemic Lupus Erythematosus hypertension did not occur in a higher frequency than normal. In five cases cardiac catheter examinations showed slight elevation of the end-diastolic pressure in the right ventricle, in two cases an abnormal high mean pressure in the right atrium and a systolic gradient at the pulmonic valve was found. -Scintigrams showed definite enlargement of the spleen and to a lesser degree enlargement of the liver was seen. Laparascopy showed multiple concretions after peritonitis. Lymphographic changes in the retroperitoneal lymph nodes and lymphatic ducts were not observed in contrast to rheumatic diseases. Drug histories in most cases discovered intake of Venopyronum dragees prior to onset of the disease. But recurrent attacks of the disease also occurred without further intake of the drug.

摘要

30例患有假性红斑狼疮综合征的患者中,有13例在疾病急性期出现心脏通常可逆性增大。在2例假性红斑狼疮综合征患者中,心脏炎导致充血性心力衰竭,另有1例患者在心脏炎急性期死亡。与系统性红斑狼疮不同,高血压的发生率并不高于正常水平。5例患者进行心脏导管检查显示右心室舒张末期压力轻度升高,2例患者右心房平均压力异常升高,并发现肺动脉瓣存在收缩期梯度。闪烁扫描显示脾脏明显增大,肝脏也有较小程度的增大。腹腔镜检查显示腹膜炎后有多处结石。与风湿性疾病不同,未观察到腹膜后淋巴结和淋巴管的淋巴造影改变。大多数病例的用药史显示,在疾病发作前曾服用复方水杨酸胆碱镁片。但在未进一步服用该药的情况下,疾病也会复发。

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