Kenner L, Schwarzl F, Moshammer H, Haas F, Hoefler G, Pierer G
Department of Neurosurgery, University School of Medicine, Graz, Austria.
Br J Plast Surg. 1998 Jan;51(1):57-8. doi: 10.1054/bjps.1997.0176.
Resistance to activated protein C (APC resistance) was described recently as a cause for thrombophilia. APC inactivates coagulation co-factors Va and VIIIa. A single base-pair mutation changing Arg506 to Gln at the APC cleavage site of the factor V gene leads to a factor V Leiden variant, which is the most frequent cause of APC resistance. Recently, its role in peripheral venous thrombosis during pregnancy was described. We here report a case with thrombosis of the venous anastomoses after finger replantation with resistance to activated protein C associated with factor V Leiden mutation.
活化蛋白C抵抗（APC抵抗）最近被描述为血栓形成倾向的一个原因。APC可使凝血辅助因子Va和VIIIa失活。因子V基因的APC裂解位点处单个碱基对突变将精氨酸506变为谷氨酰胺，导致因子V莱顿变异体，这是APC抵抗最常见的原因。最近，其在妊娠期间外周静脉血栓形成中的作用也有描述。我们在此报告1例手指再植术后静脉吻合处血栓形成的病例，该病例存在与因子V莱顿突变相关的活化蛋白C抵抗。
