Wozney J M, Rosen V
Genetics Institute, Inc., Cambridge, MA 02140, USA.
Clin Orthop Relat Res. 1998 Jan(346):26-37.
The bone morphogenetic proteins are secreted signalling molecules that belong to the transforming growth factor beta family of growth and differentiation factors. Individual bone morphogenetic proteins are prominent at many sites during embryogenesis and are likely to be key regulators of early development and organogenesis. In vertebrates, one of the functions of bone morphogenetic like proteins is to induce formation of bone, cartilage, and connective tissues associated with the skeleton. This osteoinductive ability has led to the use of bone morphogenetic proteins as therapeutic agents for creation of new bone useful in treatment of skeletal injuries and diseases, and in oral and maxillofacial applications.
骨形态发生蛋白是分泌性信号分子，属于生长和分化因子的转化生长因子β家族。单个骨形态发生蛋白在胚胎发育过程中的许多部位都很突出，可能是早期发育和器官形成的关键调节因子。在脊椎动物中，类骨形态发生蛋白的功能之一是诱导与骨骼相关的骨、软骨和结缔组织的形成。这种骨诱导能力已使骨形态发生蛋白被用作治疗剂，用于生成对治疗骨骼损伤和疾病以及口腔颌面应用有用的新骨。
