Grist T M, Korosec F R, Peters D C, Witte S, Walovitch R C, Dolan R P, Bridson W E, Yucel E K, Mistretta C A
Department of Radiology, University of Wisconsin-Madison 53792-3252, USA.
Radiology. 1998 May;207(2):539-44. doi: 10.1148/radiology.207.2.9577507.
To evaluate the imaging performance and patient tolerance of a blood-pool contrast agent (MS-325) for magnetic resonance (MR) angiography.
Imaging of peripheral and carotid vessels was performed in seven healthy volunteers in a phase I clinical trial of the gadolinium chelate MS-325. Each volunteer received an intravenous injection of 0.05 mmol/kg MS-325 over 30 seconds. Dynamic (arterial phase) and steady-state (arterial-venous phase) three-dimensional gradient-echo MR angiograms were acquired during, immediately after, and approximately 50 minutes after injection. Images were ranked (1 [poor] to 5 [excellent]) for overall image quality, and signal-to-noise ratio (S/N) and contrast-to-noise ratio (C/N) were measured by using standard techniques.
All volunteers tolerated the procedure well. The MS-325-enhanced studies demonstrated intense vascular signal. Mean peripheral arterial C/N was 12.9 +/- 4.8 (standard deviation), 78.8 +/- 29.4, 46.1 +/- 10.9, and 41.9 +/- 14.1 for the two-dimensional (2D) time-of-flight (TOF) and the contrast material-enhanced dynamic, early steady-state, and late steady-state images, respectively. Image quality of steady-state postcontrast images was statistically significantly (P < .02) higher than that of 2D TOF images. Image quality of early and late postcontrast images was similar, but a small (10%) decrease in C/N was noted from early to late images.
MS-325 provides excellent vascular and selective arterial enhancement during dynamic MR angiography. The long blood residence time also allows acquisition of steady-state images of the arteries and veins with excellent spatial resolution.
评估用于磁共振（MR）血管造影的血池造影剂（MS-325）的成像性能及患者耐受性。
在钆螯合物MS-325的I期临床试验中，对7名健康志愿者的外周血管和颈动脉进行成像。每位志愿者在30秒内静脉注射0.05 mmol/kg的MS-325。在注射过程中、注射后即刻以及注射后约50分钟采集动态（动脉期）和稳态（动静脉期）三维梯度回波MR血管造影图像。对图像的整体质量进行评分（1分[差]至5分[优]），并使用标准技术测量信噪比（S/N）和对比噪声比（C/N）。
所有志愿者对该操作耐受性良好。MS-325增强研究显示血管信号强烈。二维（2D）时间飞跃（TOF）成像以及对比剂增强动态、早期稳态和晚期稳态图像的外周动脉平均C/N分别为12.9±4.8（标准差）、78.8±29.4、46.1±10.9和41.9±14.1。对比剂注射后稳态图像的质量在统计学上显著高于2D TOF图像（P <.02）。对比剂注射后早期和晚期图像的质量相似，但从早期图像到晚期图像C/N有小幅（10%）下降。
在动态MR血管造影期间，MS-325可提供出色的血管和选择性动脉增强。较长的血液驻留时间还允许采集具有出色空间分辨率的动脉和静脉稳态图像。
