Tabata M, Yoshida M, Izumi T, Kawano C, Kuribara R, Toshima M, Omine K, Takatoku M, Uchida M, Kirito K, Miyazato A, Takahashi H, Hoshino M, Terui Y, Tomizuka H, Otsuki T, Shimizu R, Tsunoda J, Muroi K, Furukawa Y, Amemiya Y, Imagawa S, Komatsu N, Suzuki T, Miura Y
Department of Medicine, Jichi Medical School.
Rinsho Ketsueki. 1998 Mar;39(3):176-84.
A retrospective analysis was performed on 76 consecutive elderly patients with acute leukemia aged 60 years or more (48 men, 28 women). Forty patients were 60-69 years old, 28 were 70-79 years old and 8 were > or = 80 years old. There were 55 patients with acute myelogenous leukemia (AML), 13 acute lymphoblastic leukemia (ALL) and 8 AML from myelodysplastic syndrome (MDS/AML). Patients were treated with the JALSG protocol, CAG regimen, or low-dose Ara-C regimen for AML, and DVP/M-CHOP protocol for ALL. The complete remission (CR) rates were 52.7% (29 of 55) in AML, 61.5% (8 of 13) in ALL, and 0% in MDS/AML. The median CR durations were 226, 85, 0 days, and the median survivals were 204, 177, 99 days, respectively. CR rates were 65.3% for the JALSG protocol, 62.5% for the CAG regimen and 25.0% for low-dose Ara-C regimen. According to age, CR was obtained 62.5% in patients aged 60-69 years and 33.3% in patients over 70 years old. Our results indicated that patients aged 60-69 years should be treated with intensive chemotherapy.
