[成人急性白血病的化疗进展]
[Progress of chemotherapy in adult acute leukemia].
作者信息
Ohno R
机构信息
Dept. of Medicine III, Hamamatsu University School of Medicine.
出版信息
Gan To Kagaku Ryoho. 1995 Mar;22(4):431-6.
Due to the advance of chemotherapy and bone marrow transplantation (BMT), adult acute leukemia has become a curable disease. Since in BMT a good prognosis is obtained in chemotherapy-induced remission cases, chemotherapy plays a major role for the cure of this disease. In acute myeloid leukemia, the JALSG AML 89 study resulted in a 77% complete remission (CR) rate in 326 adults, 38% of whom had a 4.5-year diseases-free survival (DFS) rate in CR cases. However, the results of acute lymphoblastic leukemia in the JALSG ALL 87 study were not satisfactory; 84% CR in 116 adults and only 24% 6-year DFS.
由于化疗和骨髓移植（BMT）技术的进步，成人急性白血病已成为一种可治愈的疾病。由于在骨髓移植中，化疗诱导缓解的病例预后良好，化疗在这种疾病的治愈中起着主要作用。在急性髓性白血病中，日本成人白血病研究组（JALSG）的AML 89研究在326名成人中实现了77%的完全缓解（CR）率，其中38%的完全缓解病例有4.5年的无病生存率（DFS）。然而，日本成人白血病研究组（JALSG）ALL 87研究中急性淋巴细胞白血病的结果并不理想；116名成人中的完全缓解率为84%，6年无病生存率仅为24%。
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