Vishnevskiĭ E L, Guseva N B
Urol Nefrol (Mosk). 1998 Mar-Apr(2):27-30.
An original Russian drug pikamilone with central (vegetotropic, vascular) and peripheral (vasodilation) mechanism of action and m-cholinolytic atropine were investigated for effect on detrusor function in the accumulation phase in 26 children with neurogenic bladder due to myelodysplasia. The detrusor function was assessed at retrograde cystometry performed before and after the drugs administration. The cystotonograms were estimated using a computer program of Relief urosystem according to the standard and additional indices. Pikamilone was found to potentiate the effects of atropine. This may be due to improvement of circulation and reduction of detrusor hypoxia. It is stated that selective chemotherapy of neurogenic bladder is uneffective. The preference should be given to combination of the drugs affecting main components of its dysfunction pathogenesis. Pikamilone should be referred to basic drugs for treatment of neurogenic bladder in spinal patients as its combination with atropine possesses a unique efficacy in restoration of the reservoir function of the bladder.
研究了具有中枢（植物性、血管性）和外周（血管舒张）作用机制的俄罗斯原装药物匹卡米隆以及M胆碱能阻滞剂阿托品对26例因脊髓发育不良导致神经源性膀胱的儿童在储尿期逼尿肌功能的影响。在给药前后进行逆行膀胱测压时评估逼尿肌功能。根据标准和附加指标，使用Relief urosystem计算机程序评估膀胱压力图。发现匹卡米隆可增强阿托品的作用。这可能是由于循环改善和逼尿肌缺氧减轻。据称，神经源性膀胱的选择性化疗无效。应优先选择影响其功能障碍发病机制主要成分的药物联合使用。匹卡米隆应被视为脊髓疾病患者神经源性膀胱治疗的基础药物，因为它与阿托品联合使用在恢复膀胱储尿功能方面具有独特疗效。
