Carlisle M S, Prociv P, Grennan J, Pass M A, Campbell G L, Mudie A
Department of Parasitology, University of Queensland.
Aust Vet J. 1998 Mar;76(3):167-70. doi: 10.1111/j.1751-0813.1998.tb10121.x.
Four cotton-top tamarins (Sanguinus oedipus oedipus) and one emperor tamarin (S imperator subgrisescens) housed in a zoo became depressed, anorexic, paraparetic and eventually paralysed. The animals died within 5 days to 18 months of the appearance of clinical signs. Histological examination showed nonsuppurative and eosinophilic meningoencephalitis, and metastrongyle nematode larvae were found within subarachnoid spaces of all animals and within the spinal cord of one. Intact larvae with features consistent with Angiostrongylus cantonensis were recovered from the brain of one animal. This parasite is the classical cause of eosinophilic meningoencephalitis in many parts of the world and the diagnosis can be strongly suspected on clinical grounds. In endemic areas like south-east Queensland, protection of captive animals against infection with A cantonensis is a difficult balance between providing a stimulating, natural setting and eliminating potentially infectious definitive, intermediate and paratenic hosts. This is the first report of cerebrospinal angiostrongyliasis in tamarins and nonhuman primates in Australia.
动物园里饲养的4只棉顶狨猴（红背松鼠猴指名亚种）和1只皇柽柳猴（皇柽柳猴淡灰亚种）变得抑郁、厌食、双下肢轻瘫，最终瘫痪。这些动物在出现临床症状后的5天至18个月内死亡。组织学检查显示为非化脓性嗜酸性脑膜脑炎，在所有动物的蛛网膜下腔以及其中1只动物的脊髓中发现了后圆线虫幼虫。从1只动物的大脑中发现了具有与广州管圆线虫一致特征的完整幼虫。这种寄生虫是世界许多地区嗜酸性脑膜脑炎的典型病因，根据临床症状可强烈怀疑诊断。在昆士兰东南部等流行地区，保护圈养动物免受广州管圆线虫感染是一项艰难的平衡，既要提供刺激的自然环境，又要消除潜在的感染性终末宿主、中间宿主和转续宿主。这是澳大利亚狨猴和非人灵长类动物脑脊髓管圆线虫病的首次报告。
