Plebani A, Pinzani R, Vago L, Cinque P, Triulzi F, Zibordi F, Angelini L
Department of Paediatrics, G. e D. De Marchi, University of Milan, Italy.
Eur J Pediatr. 1998 Apr;157(4):291-3. doi: 10.1007/s004310050813.
The case of a 7-month-old boy with vertically acquired immunodeficiency syndrome and multifocal primary cerebral lymphoma is reported. Neither neurological nor neuroradiological findings contributed towards the appropriate diagnosis. Positive Epstein-Barr virus DNA, assessed by means of polymerase chain reaction in cerebrospinal fluid, strongly suggested a diagnosis of primary cerebral lymphoma, which was subsequently confirmed by autopsy.
The detection of Epstein-Barr virus DNA using the polymerase chain reaction in cerebrospinal fluid is useful for the diagnosis of primary cerebral lymphoma.
