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法属圭亚那一个与世隔绝、HTLV-1感染高度流行的非洲裔人群中HTLV-1感染的人口统计学和家族特征。

Demographic and familial characteristics of HTLV-1 infection among an isolated, highly endemic population of African origin in French Guiana.

作者信息

Plancoulaine S, Buigues R P, Murphy E L, van Beveren M, Pouliquen J F, Joubert M, Rémy F, Tuppin P, Tortevoye P, de Thé G, Moreau J P, Gessain A

机构信息

Unité d'Epidémiologie des Virus Oncogènes, Institut Pasteur, Paris, France.

出版信息

Int J Cancer. 1998 May 4;76(3):331-6. doi: 10.1002/(sici)1097-0215(19980504)76:3<331::aid-ijc8>3.0.co;2-w.

Abstract

To determine the epidemiological characteristics of human T cell leukemia/lymphoma virus type I (HTLV-I) infection in the endemic village of Maripasoula, French Guiana, 1,614 persons (83.2% of the population) aged 2 to 91 years (mean age 21) were studied from November 1994 through April 1995. Plasma samples were screened by an HTLV-I ELISA and an IFA test (on MT2 cells), and positive samples were tested by an HTLV-I and -II type-specific Western blot. Overall seropositivity in the village was 6.7%, but HTLV-I infection was restricted to 3 of 6 ethnic groups, including the Noir-Marron (descendants of escaped African slaves, 8%), the Creoles (4.1%) and those of mixed Noir Marron/other ethnicity (3.6%). In the Noir-Marron population of 1,222 persons, including 606 men and 616 women and representing 76% of those tested, HTLV-I seroprevalence increased significantly with age in both sexes, reaching 40% in women older than 50 years. Univariate risk factors for HTLV-I seropositivity in women included older age, more pregnancies, more live births and a history of hospitalization. A cross-sectional analysis of sexual partners demonstrated an excess of discordant female HTLV-I+/male HTLV-I- couples, indicating preferential male-to-female sexual transmission. The demonstration of II HTLV-I-seropositive children aged less than 15 years, of whom 9 had a seropositive mother, suggested maternal-child HTLV-I transmission. Our results demonstrate a very high seroprevalence of HTLV-I in this South American population descended from African slaves, probably due to high rates of mother-to-child and sexual transmission within this rather isolated group.

摘要

为确定法属圭亚那马里帕苏拉流行村人类T细胞白血病/淋巴瘤病毒I型(HTLV-I)感染的流行病学特征,于1994年11月至1995年4月对1614名年龄在2至91岁(平均年龄21岁)的人(占总人口的83.2%)进行了研究。血浆样本通过HTLV-I酶联免疫吸附测定(ELISA)和免疫荧光分析(IFA,在MT2细胞上进行)进行筛查,阳性样本通过HTLV-I和-II型特异性蛋白质印迹法进行检测。该村庄的总体血清阳性率为6.7%,但HTLV-I感染仅限于6个族群中的3个,包括黑棕人(逃亡非洲奴隶的后裔,8%)、克里奥尔人(4.1%)以及黑棕人与其他族群混血的人群(3.6%)。在1222名黑棕人当中,包括606名男性和616名女性,占受检者的76%,HTLV-I血清阳性率在两性中均随年龄显著增加,50岁以上女性达到40%。女性HTLV-I血清阳性的单因素风险因素包括年龄较大、更多次怀孕、更多次活产以及有住院史。对性伴侣的横断面分析显示,HTLV-I阳性女性/HTLV-I阴性男性的不一致夫妇过多,表明存在男性向女性的性传播偏好。发现2名15岁以下HTLV-I血清阳性儿童,其中9名儿童的母亲血清阳性,提示存在母婴HTLV-I传播。我们的结果表明,在这个源自非洲奴隶的南美人群中,HTLV-I血清阳性率非常高,这可能是由于在这个相对隔离的群体中母婴传播和性传播率较高。

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