Plancoulaine S, Gessain A, Joubert M, Tortevoye P, Jeanne I, Talarmin A, de Thé G, Abel L
INSERM U436, "Modélisation Mathématique et Statistique en Biologie et Médecine," CHU Pitié Salpétrière, Unité d'Epidémiologie des Virus Oncogènes, Institut Pasteur, Paris, France.
J Infect Dis. 2000 Aug;182(2):405-12. doi: 10.1086/315741. Epub 2000 Jul 21.
Human T lymphotropic virus type I (HTLV-I) is a human oncoretrovirus that causes an adult T cell leukemia/lymphoma and a chronic neuromyelopathy. To investigate whether familial aggregation of HTLV-I infection (as determined by specific seropositive status) could be explained in part by genetic factors, we conducted a large genetic epidemiological survey in an HTLV-I-endemic population of African origin from French Guiana. All of the families in 2 villages were included, representing 83 pedigrees with 1638 subjects, of whom 165 (10.1%) were HTLV-I seropositive. The results of segregation analysis are consistent with the presence of a dominant major gene predisposing to HTLV-I infection, in addition to the expected familial correlations (mother-offspring, spouse-spouse) due to the virus transmission routes. Under this genetic model, approximately 1. 5% of the population is predicted to be highly predisposed to HTLV-I infection, and almost all seropositive children <10 years of age are genetic cases, whereas most HTLV-I seropositive adults are sporadic cases.
人类嗜T淋巴细胞病毒I型（HTLV-I）是一种人类嗜肝逆转录病毒，可导致成人T细胞白血病/淋巴瘤和慢性神经脊髓病。为了研究HTLV-I感染的家族聚集性（由特定血清学阳性状态确定）是否部分可由遗传因素解释，我们在法属圭亚那非洲裔HTLV-I流行人群中进行了一项大型遗传流行病学调查。纳入了2个村庄的所有家庭，代表83个家系的1638名受试者，其中165名（10.1%）为HTLV-I血清学阳性。除了由于病毒传播途径导致的预期家族相关性（母婴、配偶与配偶）外，分离分析结果与存在易患HTLV-I感染的显性主基因一致。在这种遗传模型下，预计约1.5%的人群极易感染HTLV-I，几乎所有10岁以下的血清学阳性儿童都是遗传病例，而大多数HTLV-I血清学阳性成年人是散发病例。
