Dabbagh O, Gascon G, Crowell J, Bamoggadam F
Department of Neurosciences, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Epilepsia. 1997 Sep;38(9):1045-9. doi: 10.1111/j.1528-1157.1997.tb01491.x.
A 3.5-year-old girl had epilepsia partialis continua of the right side. Clinical and laboratory findings were consistent with Rasmussen's encephalitis. Treatment with high-dose methylprednisolone led to temporary control of seizures, but for 2 years, the seizures remained refractory to phenobarbital, phenytoin, lorazepam, carbamazepine, valproic acid, vigabatrin, gabapentin, and lamotrigine. A 6-week course, and later a 6-month course, of intraventricular interferon-alpha almost totally suppressed the seizures. Although moderately hemiparetic, the child has reasonable neurologic function with mild speech delay. She is receiving her third course of treatment, and seizures remain completely controlled.
一名3.5岁女童出现右侧持续性部分性癫痫。临床和实验室检查结果符合拉斯穆森脑炎。大剂量甲泼尼龙治疗使癫痫发作得到暂时控制，但在2年时间里，苯巴比妥、苯妥英、劳拉西泮、卡马西平、丙戊酸、氨己烯酸、加巴喷丁和拉莫三嗪对癫痫发作均无效。脑室内注射α-干扰素一个6周疗程，随后一个6个月疗程，几乎完全抑制了癫痫发作。尽管有中度偏瘫，但该患儿神经功能尚可，仅有轻度语言发育迟缓。她正在接受第三个疗程的治疗，癫痫发作仍完全得到控制。
