Coulombe P, Dussault J H, Walker P
Metabolism. 1976 Sep;25(9):973-9. doi: 10.1016/0026-0495(76)90126-8.
Using a modification of the fluorometric method of Anton and Sayre, we have measured the plasma epinephrine (E) and norepinephrine (NE) concentrations in patients with thyroid dysfunction. There was no significant difference in plasma E in hyperthyroid or hypothyroid subjects, the values being similar to those observed in normal subjects. There was a striking relationship between age and plasma NE in the euthyroid individuals (r = 0.685, p less than 0.001, n = 41). Observed plasma NE concentrations were similar in control subjects (21.05 +/- 1.6 ng/100 ml; mean +/- SEM) and hyperthyroid patients (22.33+/- 2.0 ng/100 ml). However, plasma NE was significantly increased in hypothyroidism (35.46 +/- 3.9 ng/100 ml; p less than 0.01) and remained statistically different when the age factor was excluded (31.31 +/- 2.67 ng/100 ml; p less than 0.025). There was no correlation between plasma NE and serum thyroxine (T4), free thyroxine (FT4), or triiodothyronine (T3), in any of the three groups studied. These data indicate that hyperthyroidism is accompanied by normal plasma NE concentrations and that hypothyroidism is associated with significantly increased plasma NE concentrations, possible in an attempt to compensate for the lack of thyroid hormones.
采用对Anton和Sayre荧光法的一种改良方法，我们测定了甲状腺功能障碍患者血浆肾上腺素（E）和去甲肾上腺素（NE）的浓度。甲状腺功能亢进或减退患者的血浆E无显著差异，其值与正常受试者观察到的值相似。甲状腺功能正常个体的年龄与血浆NE之间存在显著关系（r = 0.685，p < 0.001，n = 41）。对照受试者（21.05±1.6 ng/100 ml；平均值±标准误）和甲状腺功能亢进患者（22.33±2.0 ng/100 ml）的血浆NE浓度相似。然而，甲状腺功能减退时血浆NE显著升高（35.46±3.9 ng/100 ml；p < 0.01），排除年龄因素后仍有统计学差异（31.31±2.67 ng/100 ml；p < 0.025）。在所研究的三组中，血浆NE与血清甲状腺素（T4）、游离甲状腺素（FT4）或三碘甲状腺原氨酸（T3）之间均无相关性。这些数据表明，甲状腺功能亢进伴随着正常的血浆NE浓度，而甲状腺功能减退与血浆NE浓度显著升高有关，这可能是试图补偿甲状腺激素的缺乏。
