Coulombe P, Dussault J H, Walker P
J Clin Endocrinol Metab. 1977 Jun;44(6):1185-9. doi: 10.1210/jcem-44-6-1185.
We have measured the secretion rate of norepinephrine (NE) in 6 euthyroid subjects, 6 hyperthyroid and 6 hypothyroid patients, infused at a constant rate (0.1 microC/kg/min) for 1 h with tritiated norepinephrine (New England Nuclear Inc.). Plasma NE concentrations were measured by a modification of the fluorometric method of Anton and Sayre. A significant linear relationship was observed between plasma NE and age in normal subjects. Accordingly, values for plasma NE have been corrected for age. Plasma NE concentration was 18.3 +/- 4.2 ng/100 ml (mean+/-SEM) in normal subjects compared with 17.5 +/- 3.3 ng/100 ml in hyperthyroid patients. There was a significant elevation of plasma NE (30.3 +/- 2.9 ng/100 ml) in hypothyroid patients (P less than 0.05). A significant elevation was observed in plasma NE secretion rates in hypothyroidism 4.62 +/- 0.98 microgram/kg/day (P less than 0.02) when compared to the control group (1.46 +/- 0.35 microgram/kg/day). No significant difference was observed between the hyperthyroid group (1.74 +/- 0.49 microgram/kg/day) and the controls. These data indicate that the plasma NE secretion rate is normal in hyperthyroidism, and is significantly elevated in hypothyroidism thereby explaining the higher plasma NE concentrations seen in hypothyroidism.
我们用氚标记的去甲肾上腺素（新英格兰核公司）以恒定速率（0.1微居里/千克/分钟）给6名甲状腺功能正常的受试者、6名甲状腺功能亢进患者和6名甲状腺功能减退患者输注1小时，测量了去甲肾上腺素（NE）的分泌率。血浆NE浓度采用对Anton和Sayre荧光法的改良方法进行测定。在正常受试者中观察到血浆NE与年龄之间存在显著的线性关系。因此，已对血浆NE值进行了年龄校正。正常受试者的血浆NE浓度为18.3±4.2纳克/100毫升（平均值±标准误），而甲状腺功能亢进患者为17.5±3.3纳克/100毫升。甲状腺功能减退患者的血浆NE显著升高（30.3±2.9纳克/100毫升）（P＜0.05）。与对照组（1.46±0.35微克/千克/天）相比，甲状腺功能减退患者的血浆NE分泌率显著升高，为4.62±0.98微克/千克/天（P＜0.02）。甲状腺功能亢进组（1.74±0.49微克/千克/天）与对照组之间未观察到显著差异。这些数据表明，甲状腺功能亢进时血浆NE分泌率正常，而甲状腺功能减退时显著升高，从而解释了甲状腺功能减退时血浆NE浓度较高的现象。
