异基因骨髓移植治疗T原淋巴细胞白血病。
Treatment of T prolymphocytic leukemia with allogeneic bone marrow transplantation.
作者信息
Collins R H, Piñeiro L A, Agura E D, Fay J W
机构信息
Bone Marrow Transplantation, Baylor University Medical Center/Texas Oncology, Dallas 75246, USA.
出版信息
Bone Marrow Transplant. 1998 Mar;21(6):627-8. doi: 10.1038/sj.bmt.1701127.
T prolymphocytic leukemia (T-PLL) is an unusual disease characterized by high white cell counts, older age at presentation, splenomegaly and a very aggressive clinical course. We describe a 47-year-old male with refractory T-PLL who was treated with high-dose chemoradiotherapy and allogeneic bone marrow transplantation (BMT) from an HLA-matched sibling. The transplant was complicated by both acute and chronic graft-versus-host disease (GVHD). The patient achieved complete remission and remains in remission 3 years after the transplant.
T 细胞幼淋巴细胞白血病（T-PLL）是一种罕见疾病，其特征为白细胞计数高、发病时年龄较大、脾肿大以及临床病程极为凶险。我们描述了一名 47 岁难治性 T-PLL 男性患者，他接受了大剂量放化疗以及来自 HLA 匹配同胞的异基因骨髓移植（BMT）。移植过程并发了急性和慢性移植物抗宿主病（GVHD）。患者实现了完全缓解，移植后 3 年仍处于缓解状态。
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