Fernández-Martín J L, Douthat W, Barreto S, Canteros A, Acuña G, Cannata Andía J B
Bone and Mineral Research Unit, Instituto Reina Sofía de Investigación, Hospital Central de Asturias, Universidad de Oviedo, Spain.
Nephrol Dial Transplant. 1998;13 Suppl 3:82-7. doi: 10.1093/ndt/13.suppl_3.82.
Several dialysis techniques have been used to improve aluminium removal. So far there are no data available using paired filtration-dialysis (PFD). In this study, we evaluated the aluminium removed by PFD in two phases. Bovine plasma with known concentrations of aluminium and desferrioxamine was used in both experiments. In phase I, the aluminium removal was investigated using the PFD system (single pass) in its usual configuration, modifying the order of the convective and diffusive processes, dialysis with high permeability membranes and dialysis with low permeability membranes. During the second phase, the experiment lasted longer using recirculation, and the PFD was compared with conventional dialysis using high permeability membranes. Changes in the PFD configuration did not alter the aluminium removal; the efficiency of PFD for aluminium removal was very close to that of dialysis with high permeability membranes and much greater than with low permeability membranes. The aluminium is removed mainly in the first part of the dialysis. Aluminium mobilization using the double chamber technique (PFD) was efficient and might be of value for those patients with aluminium overload who needs high depurative techniques and are unable to tolerate high-flux techniques.
已经采用了几种透析技术来提高铝的清除率。到目前为止，尚无关于配对过滤透析（PFD）的数据。在本研究中，我们分两个阶段评估了PFD对铝的清除情况。两个实验均使用了已知铝浓度和去铁胺的牛血浆。在第一阶段，使用常规配置的PFD系统（单程）研究铝的清除情况，改变对流和扩散过程的顺序，使用高通透性膜透析和低通透性膜透析。在第二阶段，使用再循环使实验持续时间更长，并将PFD与使用高通透性膜的传统透析进行比较。PFD配置的改变并未改变铝的清除率；PFD去除铝的效率与使用高通透性膜透析的效率非常接近，远高于使用低通透性膜透析的效率。铝主要在透析的第一部分被清除。使用双腔技术（PFD）进行铝动员是有效的，对于那些铝过载且需要高净化技术但无法耐受高通量技术的患者可能具有价值。
