Baki A, Karagüzel G
Department of Pediatrics, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.
Acta Paediatr Jpn. 1998 Apr;40(2):135-7. doi: 10.1111/j.1442-200x.1998.tb01897.x.
A review of the literature highlights the need for research, particularly on the acute bronchodilatory effect of salmeterol on bronchoconstriction in the pediatric age group. The present study attempted to evaluate the acute bronchodilatory effect of salmeterol on methacholine-induced bronchoconstriction in childhood asthma and to compare it with the effect of salbutamol. Forty-four asymptomatic children with mild-to-moderate asthma (23 boys and 21 girls; aged 7-17 years) were studied. At the beginning, the baseline forced expiratory volume in 1 s (FEV1) was measured, and the methacholine challenge was performed by doubling the dose to determine PC20 (provocative concentration of inhaled methacholine required to reduce FEV1 by 20%). At the same time, the transcutaneous arterial oxygen saturation (SaO2) was also measured. Each subject inhaled a single dose of 25 micrograms salmeterol (n: 23, group I) or 100 micrograms salbutamol (n: 21, group II) following the SaO2 measurement. The same measurements (FEV1, SaO2) were repeated 5 and 20 min after the inhalation. After inhalation of salmeterol or salbutamol, the differences between the values of FEV1 and SaO2 after 5 and 20 min were insignificant in both group I and group II (P > 0.05), although there was a significant improvement in both FEV1 and SaO2 after 5 and 20 min (P < 0.005). From these findings it was concluded that salmeterol can be considered as effective as salbutamol on methacholine-induced bronchoconstriction.
文献综述强调了开展研究的必要性，特别是关于沙美特罗对儿童年龄组支气管收缩的急性支气管扩张作用的研究。本研究试图评估沙美特罗对儿童哮喘中乙酰甲胆碱诱导的支气管收缩的急性支气管扩张作用，并将其与沙丁胺醇的作用进行比较。对44名轻度至中度哮喘的无症状儿童（23名男孩和21名女孩；年龄7 - 17岁）进行了研究。开始时，测量基线第1秒用力呼气量（FEV1），并通过将剂量加倍来进行乙酰甲胆碱激发试验以确定PC20（使FEV1降低20%所需的吸入乙酰甲胆碱的激发浓度）。同时，还测量经皮动脉血氧饱和度（SaO2）。在测量SaO2后，每组受试者吸入单剂量25微克沙美特罗（n = 23，第一组）或100微克沙丁胺醇（n = 21，第二组）。吸入后5分钟和20分钟重复相同测量（FEV1、SaO2）。吸入沙美特罗或沙丁胺醇后，第一组和第二组在5分钟和20分钟后FEV1和SaO2值的差异均无统计学意义（P > 0.05），尽管在5分钟和20分钟后FEV1和SaO2均有显著改善（P < 0.005）。从这些发现得出结论，在乙酰甲胆碱诱导的支气管收缩方面，沙美特罗可被认为与沙丁胺醇同样有效。
