Lai M M
Howard Hughes Medical Institute and Department of Molecular Microbiology and Immunology, University of Southern California School of Medicine, Los Angeles 90033-1054, USA.
Virology. 1998 Apr 25;244(1):1-12. doi: 10.1006/viro.1998.9098.
Viral RNA replication and transcription involves not only viral RNA-dependent RNA polymerases, but also cellular proteins, the majority of which are subverted from the RNA-processing or translation machineries of host cells. These factors interact with viral RNA or polymerases to form transcription or replication ribonucleoprotein complexes and may provide template specificity for RNA-dependent RNA synthesis, suggesting a close parallel to the mechanism of DNA-dependent RNA synthesis. The types of cellular proteins involved and their modes of action are reviewed.
病毒RNA复制和转录不仅涉及病毒RNA依赖性RNA聚合酶，还涉及细胞蛋白，其中大多数是从宿主细胞的RNA加工或翻译机制中被篡夺的。这些因子与病毒RNA或聚合酶相互作用，形成转录或复制核糖核蛋白复合物，并可能为RNA依赖性RNA合成提供模板特异性，这表明其与DNA依赖性RNA合成机制非常相似。本文综述了所涉及的细胞蛋白类型及其作用方式。
