Chromosome damage induced by semicarbazide in spermatocytes of a grasshopper.

Semicarbazide hydrochloride (0.1 M in glass-distilled water), on injection, showed mutagenic action on the spermatocyte chromosomes of the grasshopper, Spathosternum prasiniferum. Aberrations such as chromatid and chromosome breaks, translocations, fragments and bridges were encountered. The sex chromosome and the long autosomes were affected. Semicarbazide, perhaps, reacts with DNA and the chromosome in a way similar to that of hydroxylamine and hydrazines.