精神分裂症患者脑脊液中神经元细胞黏附分子升高的进一步研究。
Further studies of elevated cerebrospinal fluid neuronal cell adhesion molecule in schizophrenia.
作者信息
van Kammen D P, Poltorak M, Kelley M E, Yao J K, Gurklis J A, Peters J L, Hemperly J J, Wright R D, Freed W J
机构信息
Veterans Affairs Medical Center, Highland Drive Division, Pittsburgh, Pennsylvania 15206, USA.
出版信息
Biol Psychiatry. 1998 May 1;43(9):680-6. doi: 10.1016/s0006-3223(97)00324-7.
BACKGROUND
The purposes of the present study were to attempt to replicate a previous finding of increased cerebrospinal fluid (CSF) neuronal cell adhesion molecule (N-CAM) in schizophrenia, and to assess whether the increases could be related to medication, clinical state effects, or brain structural measures.
METHODS
CSF N-CAM was measured by the Western blot technique in 45 DSM-III-R diagnosed male schizophrenic patients both on and off haloperidol treatment and in 20 healthy male control subjects.
RESULTS
CSF N-CAM was significantly increased in schizophrenic patients, with no overlap in the ranges, when compared to controls. There were no significant effects of medication or exacerbation on CSF N-CAM. No associations with measures of brain structure were found.
CONCLUSIONS
Because N-CAM levels were not shown to be different on and off treatment or in exacerbated versus nonexacerbated patients, the higher levels seen in schizophrenic patients may be inherent to the disorder and possibly related to neurodevelopment.
背景
本研究的目的是尝试重复先前关于精神分裂症患者脑脊液（CSF）中神经元细胞粘附分子（N-CAM）增加的发现，并评估这种增加是否与药物治疗、临床状态影响或脑结构测量指标有关。
方法
采用蛋白质免疫印迹技术，对45例符合《精神疾病诊断与统计手册》第三版修订版（DSM-III-R）诊断标准的男性精神分裂症患者进行了检测，这些患者分别处于服用氟哌啶醇治疗和未治疗状态，同时选取了20名健康男性作为对照。
结果
与对照组相比，精神分裂症患者脑脊液中的N-CAM显著增加，且两组范围无重叠。药物治疗或病情加重对脑脊液N-CAM无显著影响。未发现与脑结构测量指标有相关性。
结论
由于未显示治疗前后或病情加重与未加重患者的N-CAM水平存在差异，因此精神分裂症患者中较高的N-CAM水平可能是该疾病所固有的，并且可能与神经发育有关。
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