活体亲属部分肝移植治疗原发性胆汁性肝硬化——病例报告

Living related partial liver transplantation for primary biliary cirrhosis--a case report.

作者信息

Asahara T, Dohi K, Sugino K, Marubayashi S, Ohdan H, Noriyuki T, Katayama K, Itamoto T, Nakanishi T, Tazuma S, Kajiyama G, Moriwaki K, Yuge O, Otani M, Okabayashi S, Yokoyama T, Shimamoto F, Itoh H, Yokoyama T

机构信息

2nd Department of Surgery, Hiroshima University School of Medicine, Japan.

出版信息

Hiroshima J Med Sci. 1998 Mar;47(1):31-7.

PMID:9583281

Abstract

An adult living related partial liver transplantation was performed on a 49 year old female with terminal hepatic failure due to primary biliary cirrhosis (PBC). The donor was her 53 year-old sister. A sufficient volume of graft tissue was obtained, which comprised 1.5% of the body weight of the recipient. The recipient had an excellent recovery without any major complications, and was discharged 35 days after the operation. At 15 months after the operation, the patient has shown no signs of rejection while using FK506 and prednisolone as immunosuppressants. The progression of symptomatic PBC can be predicted, and the timing of the transplantation can be easily determined. In addition, the results of liver transplantation for PBC are good. Therefore, adult living related partial liver transplantation is an excellent treatment for primary biliary cirrhosis.

摘要

对一名因原发性胆汁性肝硬化（PBC）导致终末期肝衰竭的49岁女性进行了成人活体亲属部分肝移植。供体是她53岁的姐姐。获取了足够体积的移植组织，其占受体体重的1.5%。受体恢复良好，无任何重大并发症，术后35天出院。术后15个月，患者在使用FK506和泼尼松龙作为免疫抑制剂时未出现排斥迹象。有症状的PBC的进展可以预测，移植时机也很容易确定。此外，PBC肝移植的效果良好。因此，成人活体亲属部分肝移植是原发性胆汁性肝硬化的一种优秀治疗方法。