Kronenberg M F, Laimer I, Rifici C, Saltuari L, Bramanti P, Moriggl U, Norer B, Kofler A
Department of Neurology, University Hospital Innsbruck, Austria.
Pain. 1998 Apr;75(2-3):383-7. doi: 10.1016/s0304-3959(97)00173-5.
We report on two patients with morphine-related seizures associated with either intrathecal or intracerebroventricular administration. Both patients had a history of malignant tumor and both experienced the seizures following bolus application of morphine, while even higher dosages were well tolerated when continuously infused. Seizures occurred without signs of intoxication. Initiation of intrathecal morphine therapy and bolus application should be performed carefully and only when constant monitoring is provided for at least 12 h. Animal data and possible mechanisms for morphine-related seizures are discussed.
我们报告了两例与鞘内或脑室内注射吗啡相关的癫痫发作患者。两名患者均有恶性肿瘤病史，且均在静脉推注吗啡后出现癫痫发作，而持续输注时即使剂量更高也耐受性良好。癫痫发作时无中毒迹象。鞘内吗啡治疗的开始和推注应谨慎进行，且仅在至少12小时持续监测的情况下进行。本文还讨论了动物实验数据以及吗啡相关癫痫发作的可能机制。
