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[蛔虫(似蚓蛔线虫)中抗氧化防御酶的存在]

[The presence of antioxidative defense enzymes in the ascarid Ascaris lumbricoides].

作者信息

Gerasimov A M, Kasatkina N V, Darmova E N

出版信息

Zh Evol Biokhim Fiziol. 1979 Mar-Apr;15(2):126-30.

PMID:95848
Abstract

Superoxide dismutase, glutathione peroxidase and glutathione have been discovered in muscles of the ringworm A. lumbricoides. Superoxide dismutase activity was also revealed in eggs and larvae. Using polyacrylamide gel electrophoresis and electrofocusing, it was shown that this enzyme exists in ringworm muscles in multiple molecular forms. Oxygen poisoning of the ringworm and aerobic incubation of muscle homogenates in the presence of Fe+2 do not result in accumulation of malonyldialdehyde. Biochemical defence mechanisms are discussed against oxygen poisoning of the organisms which live under the conditions of reduced and changing pO2.

摘要

在蛔虫肌肉中发现了超氧化物歧化酶、谷胱甘肽过氧化物酶和谷胱甘肽。在虫卵和幼虫中也检测到了超氧化物歧化酶活性。通过聚丙烯酰胺凝胶电泳和聚焦电泳表明,该酶在蛔虫肌肉中以多种分子形式存在。蛔虫的氧中毒以及肌肉匀浆在Fe²⁺存在下的需氧孵育均未导致丙二醛积累。文中讨论了生活在低氧且变化的pO₂条件下的生物针对氧中毒的生化防御机制。

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