前列腺酸性磷酸酶：L-(+)-酒石酸离子抑制作用的结构方面
Prostatic acid phosphatase: structural aspects of inhibition by L-(+)-tartrate ions.
作者信息
Lovelace L, Lewiński K, Jakob C G, Kuciel R, Ostrowski W, Lebioda L
机构信息
Department of Chemistry and Biochemistry, University of South Carolina, Columbia 29208, USA.
出版信息
Acta Biochim Pol. 1997;44(4):673-8.
PMID:9584847
Abstract
The crystal structure of the complex between rat-prostatic acid phosphatase (PAP) and L-(+)-tartrate (Lindqvist et al., J. Biol. Chem., 1993, 268, 20744-20746) contains the model of the ligand with incorrect chirality. We report here the correct model and discuss the relation between this model and the model of the inhibitory complexes between PAP and oxy-anions.
摘要
大鼠前列腺酸性磷酸酶（PAP）与L-(+)-酒石酸复合物的晶体结构（Lindqvist等人，《生物化学杂志》，1993年，第268卷，20744 - 20746页）包含了手性错误的配体模型。我们在此报告正确的模型，并讨论该模型与PAP和氧阴离子之间抑制性复合物模型的关系。
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