Pajor L, Matolcsy A, Vass J A, Méhes G, Marton E, Szabó F, Iványi J L
Department of Pathology, University Medical School of Pécs, Hungary.
Leuk Res. 1998 Jan;22(1):13-7. doi: 10.1016/s0145-2126(97)00131-8.
The case history of a 70-year-old man with myelodysplastic syndrome terminated into acute leukemia in 22 months is presented. The leukemic cells exhibited multifocal acid phosphatase positivity and expressed TdT, CD45, CD34 and HLA-DR but not myeloid, monocytic or megakaryocytic differentiation antigenes. The genotypic analysis revealed clonal immunoglobulin heavy chain gene rearrangement. These phenotypic and genotypic analyses of the blastic cell population suggest that myelodysplastic syndrome may transform to pure acute lymphoblastic leukemia of B-cell origin.
本文报告了一名70岁男性骨髓增生异常综合征患者的病例，该患者在22个月后发展为急性白血病。白血病细胞表现出多灶性酸性磷酸酶阳性，并表达末端脱氧核苷酸转移酶（TdT）、CD45、CD34和人类白细胞抗原-DR（HLA-DR），但不表达髓系、单核系或巨核系分化抗原。基因分型分析显示存在克隆性免疫球蛋白重链基因重排。对原始细胞群的这些表型和基因分型分析表明，骨髓增生异常综合征可能转化为B细胞起源的纯急性淋巴细胞白血病。
