Felice K J
Department of Neurology, University of Connecticut School of Medicine, Farmington 06030-1840, USA.
Muscle Nerve. 1998 Jun;21(6):756-61. doi: 10.1002/(sici)1097-4598(199806)21:6<756::aid-mus7>3.0.co;2-6.
The motor unit number estimate (MUNE), motor unit size, and conduction velocity (CV) of thenar surface-recorded motor unit action potentials (S-MUAPs) as collected by the automated F-wave technique were analyzed in 13 patients with amyotrophic lateral sclerosis (ALS) (aged 29-78 years, mean: 61) and 10 age-matched normal subjects (aged 49-81 years, mean: 64). Totals of 96 and 100 thenar S-MUAPs were collected from ALS patients and normal subjects, respectively. There were significant differences (P < 0.001) in the mean estimated numbers and sizes of motor units between the ALS patients (MUNE: 41.9, S-MUAP size: 699.6 microV/ms) and normal subjects (MUNE: 151.2, S-MUAP size: 244.1 microV/ms). The mean S-MUAP CV was 46.3 m/s (range: 32-59) for ALS patients and 56.5 m/s (range: 43-69) for normal subjects (P < 0.001). Mean median motor nerve CVs, measured in the forearm segment, were not significantly different (P = 0.79) between ALS patients (53.4 m/s) and normal subjects (52.9 m/s), however. Thenar motor unit CVs are significantly reduced in ALS patients as compared to normal controls, and this may be due to proximal motor nerve slowing.
采用自动F波技术收集13例肌萎缩侧索硬化症（ALS）患者（年龄29 - 78岁，平均61岁）和10例年龄匹配的正常受试者（年龄49 - 81岁，平均64岁）大鱼际表面记录的运动单位动作电位（S - MUAPs），分析其运动单位数量估计（MUNE）、运动单位大小和传导速度（CV）。分别从ALS患者和正常受试者中收集到96个和100个大鱼际S - MUAPs。ALS患者（MUNE：41.9，S - MUAP大小：699.6微伏/毫秒）和正常受试者（MUNE：151.2，S - MUAP大小：244.1微伏/毫秒）之间运动单位的平均估计数量和大小存在显著差异（P < 0.001）。ALS患者的平均S - MUAP CV为46.3米/秒（范围：32 - 59），正常受试者为56.5米/秒（范围：43 - 69）（P < 0.001）。然而，在前臂段测量的平均正中运动神经CVs在ALS患者（53.4米/秒）和正常受试者（52.9米/秒）之间无显著差异（P = 0.79）。与正常对照组相比，ALS患者的大鱼际运动单位CVs显著降低，这可能是由于近端运动神经减慢所致。
