Kamiuchi T, Imanishi M, Abe E, Sugiura Y
Institute for Chemical Research, Kyoto University, Japan.
Nucleic Acids Symp Ser. 1997(37):153-4.
New six zinc finger protein DSp1 was created by connecting two Sp1 DNA binding domains. The DNA recognition characteristics of DSp1 demonstrate that (1) this multi finger protein binds eighteen contiguous base pairs of DNA sequence, (2) each zinc finger wraps around DNA major groove, and (3) two Sp1 domains have nonequivalent contribution to the DNA binding of DSp1.
通过连接两个Sp1 DNA结合结构域创建了新的六锌指蛋白DSp1。DSp1的DNA识别特征表明：（1）这种多锌指蛋白结合18个连续的DNA序列碱基对；（2）每个锌指环绕DNA大沟；（3）两个Sp1结构域对DSp1的DNA结合贡献不等同。
