凝血酶适体衍生物的凝血酶结合特性。
Thrombin-binding properties of thrombin aptamer derivatives.
作者信息
Sumikura K, Yano K, Ikebukuro K, Karube I
机构信息
Research Center for Advanced Science and Technology, University of Tokyo, Japan.
出版信息
Nucleic Acids Symp Ser. 1997(37):257-8.
PMID:9586097
Abstract
We synthesized a single-stranded DNA with triple G-quartet structure and found that its thrombin-binding activity at 37 degrees C is as much as that of thrombin aptamer with double G-quartet structure which is a product of in vitro selection and amplification. This result suggests that the sequence motifs obtained by in vitro selection and amplification method might not be the only answer.
摘要
我们合成了具有三重G-四链体结构的单链DNA，并发现其在37摄氏度时的凝血酶结合活性与具有双重G-四链体结构的凝血酶适体相当，后者是体外筛选和扩增的产物。这一结果表明，通过体外筛选和扩增方法获得的序列基序可能不是唯一的答案。
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