含DNA作为银离子载体的抗菌藻酸盐膜的制备与表征
Preparation and characterization of antibacterial alginate film containing DNA as a carrier of silver ion.
作者信息
Kitamura H, Kondo Y, Sakairi N, Nishi N
机构信息
Division of Bioscience, Graduate School of Environmental Earth Science, Hokkaido University, Sapporo, Japan.
出版信息
Nucleic Acids Symp Ser. 1997(37):273-4.
Silver ion was effectively bound to alginate film by the aid of DNA. Amounts of Ag(I) bound to the films (18 mm x 18 mm) were 4.2 micrograms and 24.7 micrograms in the absence and presence of DNA, respectively. The Ag(I)-induced films showed antibacterial activity for both of Escherichiacoli (E. coli) and Staphylococcus aureus (S. aureus), and the activity of DNA-alginate film was obviously larger than alginate film. These results indicate that Ag(I) induced in the DNA-alginate film keeps the potent antibacterial activity, and so DNA is very useful as a carrier of silver ion in the alginate film.
借助DNA，银离子有效地结合到藻酸盐膜上。在不存在和存在DNA的情况下，结合到膜（18毫米×18毫米）上的Ag(I)量分别为4.2微克和24.7微克。Ag(I)诱导的膜对大肠杆菌（E. coli）和金黄色葡萄球菌（S. aureus）均表现出抗菌活性，且DNA-藻酸盐膜的活性明显大于藻酸盐膜。这些结果表明，在DNA-藻酸盐膜中诱导产生的Ag(I)保持了强大的抗菌活性，因此DNA作为藻酸盐膜中银离子的载体非常有用。
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