Universidad CES-Grupo de Investigación en Ciencias Farmacéuticas (ICIF-CES), Programa de Química Farmacéutica, Facultad de Ciencias y Biotecnología, Universidad CES, 050021 Medellin, Antioquia, Colombia.
Universidad EIA-Grupo de Investigación en Ingeniería Biomédica EIA-CES (GIBEC), Departamento de Ingeniería Biomédica, Las Palmas Campus, Universidad EIA and Universidad CES, 055420 Envigado, Antioquia, Colombia.
Mar Drugs. 2017 Oct 24;15(10):328. doi: 10.3390/md15100328.
is a perennial plant employed for medical, pharmaceutical and cosmetic purposes that is rich in amino acids, enzymes, vitamins and polysaccharides, which are responsible for its therapeutic properties. Incorporating these properties into a biopolymer film obtained from alginate and chitosan allowed the development of a novel wound dressing with antibacterial capacity and healing effects to integrate the antibacterial capacity of silver nanoparticles with the healing and emollient properties of gel. Three alginate-chitosan matrices were obtained through blending methods using different proportions of alginate, chitosan, the (AV) gel and silver nanoparticles (AgNps), which were incorporated into the polymeric system through immersion methods. Physical, chemical and antibacterial characteristics were evaluated in each matrix. Interaction between alginate and chitosan was identified using the Fourier transform infrared spectroscopy technique (FTIR), porosity was studied using scanning electron microscopy (SEM), swelling degree was calculated by difference in weight, gel release capacity was estimated by applying a drug model (Peppas) and finally antibacterial capacity was evaluated against and . Results show that alginate-chitosan (A (1:3 Chit 1/Alg 1); B (1:3 Chit 1.5/Alg 1) and C (3:1 Chit 1/Alg 1/B12)) matrices with (AV) gel and silver nanoparticles (AgNps) described here displayed antibacterial properties and absorption and release capacity making it a potential wound dressing for minor injuries.
是一种多年生植物，因其富含氨基酸、酶、维生素和多糖而被用于医学、制药和化妆品领域，这些物质赋予了其治疗特性。将这些特性融入到由藻酸盐和壳聚糖制成的生物聚合物膜中，开发出了一种具有抗菌能力和愈合效果的新型伤口敷料，将银纳米粒子的抗菌能力与凝胶的愈合和滋润特性结合在一起。通过混合方法获得了三种藻酸盐-壳聚糖基质，使用不同比例的藻酸盐、壳聚糖、（AV）凝胶和银纳米粒子（AgNps），通过浸渍法将其掺入聚合物系统中。在每个基质中都评估了物理、化学和抗菌特性。使用傅里叶变换红外光谱技术（FTIR）鉴定了藻酸盐和壳聚糖之间的相互作用，通过扫描电子显微镜（SEM）研究了孔隙率，通过重量差计算了溶胀度，通过应用药物模型（Peppas）估算了凝胶释放能力，最后评估了对 和 的抗菌能力。结果表明，这里描述的含有（AV）凝胶和银纳米粒子（AgNps）的藻酸盐-壳聚糖（A（1:3 Chit 1/Alg 1）；B（1:3 Chit 1.5/Alg 1）和 C（3:1 Chit 1/Alg 1/B12））基质具有抗菌性能以及吸收和释放能力，使其成为治疗轻微伤口的潜在伤口敷料。
