Bodner J, Ebenbichler C F, Lechleitner M, Ritsch A, Sandhofer A, Gander R, Wolf H J, Huter O, Patsch J R
Universitiätsklinik für Innere Medizin, Innsbruck, Osterreich.
Wien Klin Wochenschr. 1998 Mar 27;110(6):212-9.
The discovery of leptin, the product of the obese (ob)-gene, has broadened the horizons of research on energy balance. This hormone, produced and secreted by adipose tissue and some placental cells, finds its way to the hypothalamus, where it binds to the leptin receptors and signals satiety through the neuroendocrine axis. The fact that adipose tissue is not merely a storage depot, but also an important endocrine tissue, has revived the interest in the "lipostatic" theory of body fat regulation and has initiated many research efforts in the field of obesity, anorexia nervosa, bulimia, reproduction and haematology.
肥胖（ob）基因产物瘦素的发现拓宽了能量平衡研究的视野。这种由脂肪组织和一些胎盘细胞产生并分泌的激素会抵达下丘脑，在那里它与瘦素受体结合，并通过神经内分泌轴发出饱腹感信号。脂肪组织不仅是一个储存库，还是一个重要的内分泌组织，这一事实重新唤起了人们对身体脂肪调节“脂肪稳态”理论的兴趣，并引发了肥胖、神经性厌食症、贪食症、生殖和血液学领域的诸多研究工作。
