De Ponte F S, Bottini D J, Maggi E, Marchetti E, Cascone P, Iannetti G
Maxillofacial Unit, La Sapienza University of Rome, Italy.
J Craniofac Surg. 1998 Mar;9(2):190-5.
Prenatal diagnosis of craniomaxillofacial malformations permits early surgery, before 6 months of life and possibly, in the near future, in utero, thereby obtaining the best aesthetic and functional results. Increased knowledge of embryology has largely improved the diagnosis of craniomaxillofacial anomalies, their classification, and therapeutic protocols. We analyzed nine pregnancies (one twin) in which cleft lip and palate (CLP)--isolated or associated with, for example, holoprosencephaly, hypertelorism, and micrognathia--was diagnosed by ultrasonography. Only one fetus of these pregnancies was later operated on in our unit. This patient, with 7 years follow-up, represents our clinical case. For these cases, early diagnosis of CLP allowed informed parental choice regarding the continuation or termination of the affected pregnancy and planning of surgical procedures to correct the malformation. This is demonstrated by the presented clinical case involving an infant operated on within 6 months with success.
颅颌面畸形的产前诊断可在出生后6个月内进行早期手术，在不久的将来甚至可能在子宫内进行手术，从而获得最佳的美学和功能效果。对胚胎学认识的增加在很大程度上改善了颅颌面畸形的诊断、分类及治疗方案。我们分析了9例妊娠（其中1例为双胞胎），这些妊娠通过超声检查诊断出唇腭裂（CLP）——孤立性唇腭裂或合并其他疾病，如前脑无裂畸形、眼距过宽和小颌畸形。这些妊娠中只有1例胎儿后来在我们科室接受了手术。该患者经过7年随访，是我们的临床病例。对于这些病例，唇腭裂的早期诊断使父母能够就是否继续妊娠或终止受影响的妊娠做出明智的选择，并为矫正畸形的外科手术制定计划。本文所展示的临床病例，即1例在6个月内接受手术且手术成功的婴儿，证实了这一点。
