Rodríguez M D, Garcia H
Department of Toxicology, National Center for Scientific Research, Havana, Cuba.
Teratog Carcinog Mutagen. 1998;18(1):1-7. doi: 10.1002/(sici)1520-6866(1998)18:1<1::aid-tcm1>3.0.co;2-k.
The effects of Policosanol, a newly developmented hypocholesterolemic drug administered during the perinatal and postnatal periods, were studied in Sprague-Dawley rats. This compound was administered orally to female rats at dose levels of 0 (control), 5, 50, and 500 mg/kg/day, from day 15 of pregnancy to day 21 after parturition. The animals were allowed to deliver and their offspring were examined for postnatal growth and development. No signs of toxic effects related to the test material were observed in the dams F0 during pregnancy and lactation. No adverse effects were observed on the postnatal growth, behaviours, or reproductive ability of pups F1. The physical and sensorial development of pups F2 was also normal. These results confirm that Policosanol does not affect the reproductive performance or fetal/neonatal development.
在斯普拉格-道利大鼠中研究了聚二十碳五烯酸（一种在围产期和产后给予的新开发的降胆固醇药物）的作用。从怀孕第15天到产后第21天，以0（对照）、5、50和500毫克/千克/天的剂量水平对雌性大鼠口服给予该化合物。让动物分娩，并检查其后代的产后生长和发育情况。在F0代母鼠怀孕和哺乳期间未观察到与受试物质相关的毒性作用迹象。在F1代幼崽的产后生长、行为或生殖能力方面未观察到不良影响。F2代幼崽的身体和感官发育也正常。这些结果证实聚二十碳五烯酸不会影响生殖性能或胎儿/新生儿发育。
