靶向内毒素的抗菌和抗炎剂。
Antibacterial and anti-inflammatory agents that target endotoxin.
作者信息
Wyckoff T J, Raetz C R, Jackman J E
机构信息
Dept of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA.
出版信息
Trends Microbiol. 1998 Apr;6(4):154-9. doi: 10.1016/s0966-842x(98)01230-x.
PMID:9587193
Abstract
Antibiotic-resistant bacterial infections are a major clinical problem. Lipid A, the active part of lipopolysaccharide endotoxins in Gram-negative bacteria, is an intriguing target for new antibacterial and anti-inflammatory agents. Inhibition of lipid A biosynthesis kills most Gram-negative bacteria, increases bacterial permeability to antibiotics and decreases endotoxin production.
摘要
抗生素耐药性细菌感染是一个主要的临床问题。脂多糖内毒素是革兰氏阴性菌中的活性成分，是新型抗菌和抗炎药物的一个有趣靶点。抑制脂多糖生物合成可杀死大多数革兰氏阴性菌，增加细菌对抗生素的通透性并减少内毒素产生。
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