Inoue H, Muneyuki H, Izumi T, Taguchi K, Nishigawa Y, Watanabe K, Ohkawa Y, Tamura N
First Department of Conservative Dentistry, Fukuoka Dental College, Japan.
J Endod. 1997 Sep;23(9):569-71. doi: 10.1016/S0099-2399(06)81123-4.
This study was designed to examine the relation between pulpal nerves and the differentiation of pulpal cells into preodontoblasts and odontoblasts during the healing process after pulpotomy. A total of 36 upper and lower teeth obtained from six adult dogs were used. The pulp chamber was opened with a sterile diamond bur, the coronal pulp was exposed, and the whole surface of the amputated pulp was capped with calcium hydroxide. The interval between pulpotomy and extraction was 5, 7, 10, 15, 20, 30, 40, 50, and 60 days, and then specimens were examined ultrastructurally. Close contact between fibroblast-like cells/osteoblast-like cells and nerve terminals at the calcification front was observed in the early healing process after pulpotomy, suggesting a close relation between nerve fibers and pulpal cell differentiation.
本研究旨在探讨牙髓切断术后愈合过程中牙髓神经与牙髓细胞分化为前成牙本质细胞和成牙本质细胞之间的关系。共使用了从六只成年犬获取的36颗上下颌牙齿。用无菌金刚砂钻打开髓腔，暴露冠髓，将切断牙髓的整个表面覆盖氢氧化钙。牙髓切断术与拔牙之间的间隔时间为5、7、10、15、20、30、40、50和60天，然后对标本进行超微结构检查。在牙髓切断术后的早期愈合过程中，观察到成纤维细胞样细胞/成骨细胞样细胞与钙化前沿的神经末梢紧密接触，提示神经纤维与牙髓细胞分化之间存在密切关系。
