Bénard J, Ahomadégbé J C
Département de biologie clinique, Institut Gustave-Roussy, Villejuif.
Bull Cancer. 1997 Dec;84(12):1141-2.
In January 1997, PCR genomic analysis of the TSG101 gene showed frequent large intragenic deletions. The investigators used a small cohort of sporadic breast cancers. Li et al. proposed human TSG101 as a breast tumor suppressor gene. Since then, several teams have worked on large series of breast cancers, using a variety of techniques. They have shown that intragenic deletion, if it exists at all, is rare. Is TSG101 a tumor gene or an impostor?
1997年1月，对TSG101基因的聚合酶链反应（PCR）基因组分析显示，该基因频繁出现大的基因内缺失。研究人员使用了一小群散发性乳腺癌病例。李等人提出将人类TSG101基因作为一种乳腺肿瘤抑制基因。从那时起，几个研究团队运用各种技术对大量乳腺癌病例展开了研究。他们发现，即便存在基因内缺失，这种情况也十分罕见。TSG101究竟是一种肿瘤基因还是徒有虚名呢？
