Lecomte C, Sabatier J M, Van Rietschoten J, Rochat H
Laboratoire de Biochimie, Ingéniérie des Protéines, CNRS UMR 6560, IFR Jean Roche, Faculté de Médecine Nord, Marseille, France.
Biochimie. 1998 Feb;80(2):151-4. doi: 10.1016/s0300-9084(98)80021-7.
In the last decade, numerous polypeptide toxins acting on ion channels have been isolated and characterized from diverse scorpion venoms. These toxins are useful pharmacological probes to study ion-specific channel proteins because they interact selectively with these channels and modulate their activities. Since low amounts of natural toxins can be isolated from scorpion venoms, the chemical synthesis approach is extremely useful to produce larger quantities of toxins and toxin analogs. This report is a succinct overview of the possibilities offered by the chemical synthesis to investigate pharmacological and structural properties of these compounds.
在过去十年中，已从各种蝎毒中分离并鉴定出许多作用于离子通道的多肽毒素。这些毒素是研究离子特异性通道蛋白的有用药理学探针，因为它们与这些通道选择性相互作用并调节其活性。由于从蝎毒中只能分离出少量天然毒素，因此化学合成方法对于大量生产毒素和毒素类似物极为有用。本报告简要概述了化学合成在研究这些化合物的药理学和结构特性方面所提供的可能性。
