接触六氯苯的工人的免疫球蛋白水平。

Immunoglobulin levels in workers exposed to hexachlorobenzene.

作者信息

Queiroz M L, Bincoletto C, Perlingeiro R C, Quadros M R, Souza C A

机构信息

Department of Pharmacology/Hemocenter-FCM, State University of Campinas, SP, Brazil.

出版信息

Hum Exp Toxicol. 1998 Mar;17(3):172-5. doi: 10.1177/096032719801700308.

DOI:10.1177/096032719801700308

PMID:9587786

Abstract

The serum immunoglobulin (IgG, IgM and IgA) concentrations of 52 chlorinated-exposed workers were examined and compared with those of non-exposed, age- and sex-matched individuals. At the time of testing, the exposed population had mean hexachlorobenzene (HCB) blood levels of 3.84 micrograms/dl with a range of 0.1 to 16 micrograms/dl. Increased IgG and IgM levels were found in the HCB-exposed workers (P < 0.05 and P < 0.01, respectively). Hepatic function was evaluated by serum aspartate (AST) and alanine aminotransferase (ALT) activities, as well as by bilirubin levels. IgM concentrations were positively correlated with three of the studied parameters, namely, length of exposure (r = 0.367) and the activities of both AST (r = 0.367) and ALT (r = 0.507).

摘要

检测了52名接触氯的工人的血清免疫球蛋白（IgG、IgM和IgA）浓度，并与未接触、年龄和性别匹配的个体进行比较。在检测时，接触人群的六氯苯（HCB）血液平均水平为3.84微克/分升，范围为0.1至16微克/分升。在接触HCB的工人中发现IgG和IgM水平升高（分别为P < 0.05和P < 0.01）。通过血清天冬氨酸（AST）和丙氨酸转氨酶（ALT）活性以及胆红素水平评估肝功能。IgM浓度与三个研究参数呈正相关，即接触时长（r = 0.367）以及AST（r = 0.367）和ALT（r = 0.507）的活性。