通过添加高度多态性的DYS385基因座提高基于STR的Y特异性单倍型的法医鉴定效率。

Increased forensic efficiency of a STR-based Y-specific haplotype by addition of the highly polymorphic DYS385 locus.

作者信息

Caglià A, Dobosz M, Boschi I, d'Aloja E, Pascali V L

机构信息

Istituto di Medicina Università Cattolica, Roma, Italy.

出版信息

Int J Legal Med. 1998;111(3):142-6. doi: 10.1007/s004140050134.

DOI:10.1007/s004140050134

PMID:9587796

Abstract

The polymorphic short tandem repeat (STR) locus DYS385 mapping to the male-specific region of human Y chromosome, was used to reinvestigate 125 unrelated Italian males, from our data archive, who had been previously typed for 7 different Y-specific STRs (DYS19, DYS389 I and II, DYS390, DYS391, DYS392, DYS393), defining a haplotype now widely adopted in the forensic context. The aim of this study was to improve the information value of the original haplotype in view of its application to issues of personal identification and parental analysis. DYS385 proved to be highly polymorphic (94.5% gene diversity) and the overall individualization capacity of the 8-loci haplotype was raised to 93.6%, with 117 unique assets out of 125 tested samples.

摘要

定位于人类Y染色体男性特异性区域的多态性短串联重复序列（STR）基因座DYS385，被用于重新研究我们数据档案中的125名无亲缘关系的意大利男性，这些男性之前已针对7个不同的Y特异性STR（DYS19、DYS389 I和II、DYS390、DYS391、DYS392、DYS393）进行过分型，确定了一种目前在法医领域广泛采用的单倍型。鉴于其在个人识别和亲子关系分析问题中的应用，本研究的目的是提高原始单倍型的信息价值。结果表明，DYS385具有高度多态性（基因多样性为94.5%），8个基因座单倍型的总体个体识别能力提高到了93.6%，在125个检测样本中有117个独特的单倍型。