正常血糖和非胰岛素依赖型糖尿病（NIDDM）病态肥胖患者中人类解偶联蛋白2（UCP 2）基因的突变筛查：法国白种人中新型UCP 2基因多态性与肥胖之间不存在关联 - Suppr

Mutation screening of the human UCP 2 gene in normoglycemic and NIDDM morbidly obese patients: lack of association between new UCP 2 polymorphisms and obesity in French Caucasians.

作者信息

Otabe S, Clement K, Rich N, Warden C, Pecqueur C, Neverova M, Raimbault S, Guy-Grand B, Basdevant A, Ricquier D, Froguel P, Vasseur F

机构信息

Institute of Biology, CNRS EP10, Lille, France.

出版信息

Diabetes. 1998 May;47(5):840-2. doi: 10.2337/diabetes.47.5.840.

DOI:10.2337/diabetes.47.5.840

PMID:9588459

Abstract

摘要

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Mutation screening of the human UCP 2 gene in normoglycemic and NIDDM morbidly obese patients: lack of association between new UCP 2 polymorphisms and obesity in French Caucasians.正常血糖和非胰岛素依赖型糖尿病（NIDDM）病态肥胖患者中人类解偶联蛋白2（UCP 2）基因的突变筛查：法国白种人中新型UCP 2基因多态性与肥胖之间不存在关联

Diabetes. 1998 May;47(5):840-2. doi: 10.2337/diabetes.47.5.840.

Frequency of and interaction between polymorphisms in the beta3-adrenergic receptor and in uncoupling proteins 1 and 2 and obesity in Germans.德国人群中β3-肾上腺素能受体、解偶联蛋白1和2基因多态性的频率及其相互作用与肥胖的关系

Int J Obes Relat Metab Disord. 2000 Oct;24(10):1239-45. doi: 10.1038/sj.ijo.0801402.

Mutation screening and association studies of the human uncoupling protein 3 gene in normoglycemic and diabetic morbidly obese patients.正常血糖和糖尿病病态肥胖患者中人类解偶联蛋白3基因的突变筛查及关联研究。

Diabetes. 1999 Jan;48(1):206-8.

Mutational analysis of the coding region of the uncoupling protein 2 gene in obese NIDDM patients: impact of a common amino acid polymorphism on juvenile and maturity onset forms of obesity and insulin resistance.肥胖型非胰岛素依赖型糖尿病患者解偶联蛋白2基因编码区的突变分析：一种常见氨基酸多态性对青少年及成年期肥胖和胰岛素抵抗发病形式的影响。

Diabetologia. 1997 Oct;40(10):1227-30. doi: 10.1007/s001250050811.

No association between the G482S polymorphism of the proliferator-activated receptor-gamma coactivator-1 (PGC-1) gene and Type II diabetes in French Caucasians.在法国白种人中，增殖激活受体γ辅激活因子-1（PGC-1）基因的G482S多态性与II型糖尿病之间无关联。

Diabetologia. 2002 Apr;45(4):602-3; author reply 604. doi: 10.1007/s00125-002-0783-z.

Genetic studies of the sulfonylurea receptor gene locus in NIDDM and in morbid obesity among French Caucasians.法国白种人中非胰岛素依赖型糖尿病及病态肥胖患者磺脲类受体基因位点的遗传学研究。

Diabetes. 1997 Apr;46(4):688-94. doi: 10.2337/diab.46.4.688.

Effects of mutations in the human uncoupling protein 3 gene on the respiratory quotient and fat oxidation in severe obesity and type 2 diabetes.人类解偶联蛋白3基因突变对重度肥胖和2型糖尿病患者呼吸商及脂肪氧化的影响。

J Clin Invest. 1998 Oct 1;102(7):1345-51. doi: 10.1172/JCI4115.

Structure and organization of the human uncoupling protein 2 gene and identification of a common biallelic variant in Caucasian and African-American subjects.人类解偶联蛋白2基因的结构与组织以及白种人和非裔美国受试者中一种常见双等位基因变体的鉴定。

Diabetes. 1998 Apr;47(4):685-7. doi: 10.2337/diabetes.47.4.685.

Structural organization and mutational analysis of the human uncoupling protein-2 (hUCP2) gene.人类解偶联蛋白2（hUCP2）基因的结构组织与突变分析

Life Sci. 1999;64(3):PL41-50. doi: 10.1016/s0024-3205(98)00555-4.

Association between polymorphisms in candidate genes and morbid obesity.候选基因多态性与病态肥胖之间的关联。

Int J Obes Relat Metab Disord. 2001 May;25 Suppl 1:S19-21. doi: 10.1038/sj.ijo.0801690.

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Uncoupling Protein 2 (UCP2) as Genetic Risk Factor for Obesity in Indonesia is Different in Gender Stratification.解偶联蛋白2（UCP2）作为印度尼西亚肥胖的遗传风险因素在性别分层上存在差异。

Kobe J Med Sci. 2018 Oct 15;64(2):E64-E72.

Obesity phenotype in relation to gene polymorphism among samples of Egyptian children and their mothers.埃及儿童及其母亲样本中肥胖表型与基因多态性的关系

Genes Dis. 2017 Dec 18;5(2):150-157. doi: 10.1016/j.gendis.2017.12.004. eCollection 2018 Jun.

Uncoupling protein 2 gene (UCP2) 45-bp I/D polymorphism is associated with adiposity among Malaysian women.解偶联蛋白2基因（UCP2）45碱基对插入/缺失多态性与马来西亚女性的肥胖有关。

J Biosci. 2014 Dec;39(5):867-75. doi: 10.1007/s12038-014-9488-y.

Association of the UCP polymorphisms with susceptibility to obesity: case-control study and meta-analysis.解偶联蛋白基因多态性与肥胖易感性的关联：病例对照研究与荟萃分析。

Mol Biol Rep. 2014 Aug;41(8):5053-67. doi: 10.1007/s11033-014-3371-7. Epub 2014 Apr 22.

UCP2 -866G/A, Ala55Val and UCP3 -55C/T polymorphisms in association with obesity susceptibility - a meta-analysis study.UCP2-866G/A、Ala55Val 和 UCP3-55C/T 多态性与肥胖易感性的关联：一项荟萃分析研究。

PLoS One. 2013;8(4):e58939. doi: 10.1371/journal.pone.0058939. Epub 2013 Apr 1.

Uncoupling proteins: role in insulin resistance and insulin insufficiency.解偶联蛋白：在胰岛素抵抗和胰岛素分泌不足中的作用

Curr Diabetes Rev. 2006 Aug;2(3):271-83. doi: 10.2174/157339906777950660.

Genomic structure and expression of uncoupling protein 2 genes in rainbow trout (Oncorhynchus mykiss).虹鳟（Oncorhynchus mykiss）解偶联蛋白2基因的基因组结构与表达

BMC Genomics. 2006 Aug 9;7:203. doi: 10.1186/1471-2164-7-203.

Candidate genes for type 2 diabetes.2型糖尿病的候选基因。

Rev Endocr Metab Disord. 2004 May;5(2):151-76. doi: 10.1023/B:REMD.0000021437.46773.26.

Lack of association between UCP2 gene polymorphisms and obesity phenotype in Italian Caucasians.意大利白种人中UCP2基因多态性与肥胖表型之间缺乏关联。

J Endocrinol Invest. 2003 Oct;26(10):985-90. doi: 10.1007/BF03348196.

Uncoupling protein 1 and 3 polymorphisms are associated with waist-to-hip ratio.解偶联蛋白1和3基因多态性与腰臀比相关。

J Mol Med (Berl). 2003 May;81(5):327-32. doi: 10.1007/s00109-003-0431-1. Epub 2003 Mar 28.

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Mutation screening of the human UCP 2 gene in normoglycemic and NIDDM morbidly obese patients: lack of association between new UCP 2 polymorphisms and obesity in French Caucasians.

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