游离皮瓣血栓形成的实验性预防。I：游离皮瓣失败模型

Experimental prevention of free flap thrombosis. I: A model of free flap failure.

作者信息

Atchabahian A, Masquelet A C

机构信息

Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA.

出版信息

Microsurgery. 1996;17(12):710-3. doi: 10.1002/(SICI)1098-2752(1996)17:12<710::AID-MICR9>3.0.CO;2-Q.

DOI:10.1002/(SICI)1098-2752(1996)17:12<710::AID-MICR9>3.0.CO;2-Q

PMID:9588717

Abstract

A model to evaluate the efficacy of therapies aimed at reducing the failure rate of microvascular free flaps was developed in the rat, inspired by earlier work on the rabbit ear by Ozbek et al. (Ann Plast Surg 32:474-477, 1994). It consisted in raising an epigastric groin flap on the femoral pedicle, while cutting the femoral artery, twisting it around the femoral vein, and resuturing it. Immediate patency was always seen, but 19 of 20 such anastomoses presented with thrombosis after 24 hours (15 venous and 4 mixed thromboses). Ten similar anastomoses performed without twisting did not result in thrombosis (P = 0.000000366). This model appears to be adequate for simulating free flap failure.

摘要

受奥兹贝克等人（《整形外科学年鉴》32:474 - 477, 1994年）早期对兔耳研究的启发，在大鼠身上建立了一个评估旨在降低游离微血管皮瓣失败率的治疗方法疗效的模型。该模型是在股血管蒂上掀起一块腹股沟区腹直肌皮瓣，同时切断股动脉，将其围绕股静脉扭转，然后重新缝合。术后总能立即观察到血管通畅，但在24小时后，20例此类吻合中有19例出现血栓形成（15例为静脉血栓，4例为混合性血栓）。10例未进行扭转的类似吻合未出现血栓形成（P = 0.000000366）。该模型似乎足以模拟游离皮瓣失败。