Atchabahian A, Masquelet A C
Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA.
Microsurgery. 1996;17(12):714-6. doi: 10.1002/(SICI)1098-2752(1996)17:12<714::AID-MICR10>3.0.CO;2-X.
A microvascular free flap failure model consisting of raising an epigastric groin flap on the femoral pedicle, while cutting the femoral artery, twisting it around the femoral vein and resuturing it, has been previously described. As it was being evaluated, normovolemic hemodilution as a means to prevent thrombosis was simultaneously assessed using an additional experimental group. Twenty percent of the blood mass of each rat was taken and replaced with a hydroxyethyl starch solution immediately before surgery. Only 14 out of 20 anastomoses presented with thrombosis (13 venous and one mixed), as opposed to 19 out of 20 animals operated on without hemodilution (P< 0.05). Normovolemic hemodilution appears to be an effective method of reducing microvascular free flap failure.
先前已描述了一种微血管游离皮瓣失败模型，该模型包括在股蒂上掀起腹股沟皮瓣，同时切断股动脉，将其绕股静脉扭转并重新缝合。在对该模型进行评估时，使用另一个实验组同时评估了等容血液稀释作为预防血栓形成的一种方法。在手术前立即抽取每只大鼠20%的血容量，并用羟乙基淀粉溶液替代。在20例吻合口中，只有14例出现血栓形成（13例为静脉血栓，1例为混合血栓），而在未进行血液稀释的20只手术动物中，有19例出现血栓形成（P<0.05）。等容血液稀释似乎是减少微血管游离皮瓣失败的有效方法。
