噻唑环孢菌素A和B，来自粘细菌褐黄孢囊菌的新型双噻唑类抗生素。
Cystothiazoles A and B, new bithiazole-type antibiotics from the myxobacterium Cystobacter fuscus.
作者信息
Ojika M, Suzuki Y, Tsukamoto A, Sakagami Y, Fudou R, Yoshimura T, Yamanaka S
机构信息
Graduate School of Bioagricultural Sciences, Nagoya University, Japan.
出版信息
J Antibiot (Tokyo). 1998 Mar;51(3):275-81. doi: 10.7164/antibiotics.51.275.
New bithiazole-type antibiotics, cystothiazoles A (C20H26N2O4S2) and B (C20H26N2O5S2), have been isolated from a culture broth of the myxobacterium, Cystobacter fuscus. The gross structures of these compounds were elucidated by spectroscopic analysis, and their absolute stereochemistry was determined by chemical degradation of cystothiazole A. Cystothiazole A inhibits fungi and human tumor cells, whereas it is inactive against bacteria. The antifungal activity appears to result from the inhibition of submitochondrial NADH oxidation. Although these compounds are structurally related to the known antibiotic myxothiazol, cystothiazole A was more active against fungi and less cytotoxic than myxothiazol.
新型噻唑类抗生素——胱硫噻唑A（C20H26N2O4S2）和胱硫噻唑B（C20H26N2O5S2），是从粘细菌fuscus的培养 broth中分离得到的。通过光谱分析阐明了这些化合物的总体结构，并通过胱硫噻唑A的化学降解确定了它们的绝对立体化学。胱硫噻唑A能抑制真菌和人类肿瘤细胞，而对细菌无活性。其抗真菌活性似乎源于对亚线粒体NADH氧化的抑制。尽管这些化合物在结构上与已知抗生素粘噻唑有关，但胱硫噻唑A对真菌的活性比粘噻唑更高，细胞毒性更低。
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