Cellini M, Possati G L, Caramazza N, Profazio V, Caramazza R
Eye Clinic, University of Bologna.
Acta Ophthalmol Scand Suppl. 1997(224):57-8. doi: 10.1111/j.1600-0420.1997.tb00483.x.
The authors assess the efficacy of flunarizine in improving blood flow and perimetric indices in low-tension glaucoma (LTG). A group of 20 patients with LTG well-compensated by medical treatment underwent Color Doppler Imaging (CDI) of the ophthalmic artery and posterior ciliary arteries with peak systolic velocity (PSV) and Purcelot's index (PI) evaluation. Computerized perimetry was also performed to assess MD, SF and CPSD. The parameters were measured before and after three months' therapy with flunarizine. Data before and after flunarizine treatment were: Ophthalmic artery- PSV 33.261 +/- 1.628 cm/sec vs 35.746 +/- 0.800 cm/sec (p < 0.001); PI 0.697 +/- 0.017 vs 0.627 +/- 0.031 (p < 0.001); Posterior ciliary arteries- PSV 9.385 +/- 0.751 cm/sec vs 10.738 +/- 1.566 cm/sec (p < 0.005); PI 0.673 +/- 0.056 vs 0.589 +/- 0.023 (p < 0.001). The perimetric indices were modified as follows: MD -11.002 +/- 6.574 vs -6.604 +/- 6.426 (p < 0.006); SF 5.05 +/- 5.717 vs 2.937 +/- 1.780 (p < 0.193); CPSD 10.198 +/- 13.392 vs 3.445 +/- 2.709 (p < 0.093). Oral administration of flunarizine, a calcium channel-blocker which acts at a vascular and neuronal level, improves the blood flow indices for the optic nerve, improving thereby the perimetric indices in LTG.
作者评估了氟桂利嗪改善低眼压性青光眼（LTG）血流和视野指标的疗效。一组20例经药物治疗病情得到良好控制的LTG患者接受了眼动脉和睫状后动脉的彩色多普勒成像（CDI）检查，并评估了收缩期峰值速度（PSV）和普尔塞洛指数（PI）。还进行了电脑视野检查以评估平均缺损（MD）、短期波动（SF）和校正模式标准差（CPSD）。在接受氟桂利嗪治疗三个月前后测量这些参数。氟桂利嗪治疗前后的数据如下：眼动脉——PSV 33.261±1.628厘米/秒对35.746±0.800厘米/秒（p<0.001）；PI 0.697±0.017对0.627±0.031（p<0.001）；睫状后动脉——PSV 9.385±0.751厘米/秒对10.738±1.566厘米/秒（p<0.005）；PI 0.673±0.056对0.589±0.023（p<0.001）。视野指标改变如下：MD -11.002±6.574对-6.604±6.426（p<0.006）；SF 5.05±5.717对2.937±1.780（p<0.193）；CPSD 10.198±13.392对3.445±2.709（p<0.093）。口服氟桂利嗪这种在血管和神经元水平起作用的钙通道阻滞剂，可改善视神经的血流指标，从而改善LTG的视野指标。
