Zakharenko L P, Zakharov I K
Institute of Cytology and Genetics, Russian Academy of Sciences, Novosibirsk, Russia.
Genetika. 1998 Mar;34(3):364-7.
Raising of gamma-irradiated larvae of Drosophila melanogaster on an ethanol-containing medium resulted in decreased mutation frequency in the wing somatic mutation and recombination test. This decrease in mutagenicity was mainly caused by the reduced recombination frequency. In lines with high activity of cytochrome P450, ethanol did not exhibit the radioprotective effect. Frequency of spontaneous mutations was significantly different in reciprocal crosses, whereas frequency of induced somatic mutations did not depend on the cross direction. Addition of 10% ethanol to the medium did not affect spontaneous mutation frequency.
在含乙醇的培养基上饲养经γ射线辐照的黑腹果蝇幼虫，导致翅体细胞突变和重组试验中的突变频率降低。这种诱变性的降低主要是由重组频率降低引起的。在细胞色素P450活性高的品系中，乙醇没有表现出辐射防护作用。自发突变频率在正反交中存在显著差异，而诱导体细胞突变频率不依赖于杂交方向。向培养基中添加10%的乙醇不影响自发突变频率。
