Noguchi S, Takase K, Kubota Y, Masuda M, Yao M, Hosaka M
Department of Urology, Yokohama City University School of Medicine.
Hinyokika Kiyo. 1998 Mar;44(3):149-53.
The prognoses and prognostic factors of the 54 patients with locally invasive bladder cancer who underwent bladder preservation therapy at Yokohama City University Hospital between 1977 and 1995 were analyzed statistically. The therapeutic modalities of bladder preservation were mainly radiation or chemotherapy. The prognosis for the patients who underwent bladder preservation therapy was worse than that for the patients who underwent total cystectomy. The prognostic factors of these patients were size and grade of tumor, presence of hydronephrosis and performance status (PS) of the patients by univariate analysis. Tumor grade was the most predictable prognostic factor using multivariate analysis. Only 17 patients survived more than 5 years after treatment; 78% of the survivors had good PS (0 or 1). Five of them died of cancer and two patients were alive with cancer. All of them had G3 tumors. These results suggest that patients with locally invasive G2 tumor could be candidates for bladder preservation therapy and patients who underwent bladder preservation therapy should be evaluated at 10 years post-therapy.
对1977年至1995年间在横滨市立大学医院接受膀胱保留治疗的54例局部浸润性膀胱癌患者的预后及预后因素进行了统计学分析。膀胱保留的治疗方式主要是放疗或化疗。接受膀胱保留治疗的患者的预后比接受全膀胱切除术的患者差。单因素分析显示，这些患者的预后因素为肿瘤大小、分级、肾积水的存在以及患者的体能状态（PS）。多因素分析显示肿瘤分级是最可预测的预后因素。治疗后仅17例患者存活超过5年；78%的幸存者PS良好（0或1）。其中5例死于癌症，2例带癌生存。他们均为G3肿瘤。这些结果表明，局部浸润性G2肿瘤患者可能是膀胱保留治疗的候选者，接受膀胱保留治疗的患者应在治疗后10年进行评估。
